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Transfer Factor

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Results for your query on April 30, 1999:
Search all fields for: transfer factor
Published in 1988
Only select references with abstracts available
Show references published in English only
Documents: 1 to 200 of 255
1 Rozzo SJ, et al; Murine transfer factor. IV. Studies with genetically regulated immune responses. (Cell Immunol, 1988 Aug, Abstract available) [MEDLINE]
2 Kirkpatrick CH; Transfer factor. (J Allergy Clin Immunol, 1988 May, Abstract available) [MEDLINE]
3 Wilson GB, et al; De novo initiation of specific cell-mediated immune responsiveness in chickens by transfer factor (specific immunity inducer) obtained from bovine colostrum and milk. (Acta Virol, 1988 Jan, Abstract available) [MEDLINE]
4 Karhumäki E, et al; Chromatographic and enzymatic effects on transfer factor-like activity from human leukocytes and porcine spleen dialysate. (Int J Biochem, 1988, Abstract available) [MEDLINE]
5 Hancock BW, et al; Transfer factor in Hodgkin's disease: a randomized clinical and immunological study. (Eur J Cancer Clin Oncol, 1988 May, Abstract available) [MEDLINE]
6 Zachar V, et al; Varicella-zoster virus IgG antibodies during primoinfection in competent and transfer factor modulated immunocompromised host: comparison of three indirect assays. (Acta Virol, 1988 May, Abstract available) [MEDLINE]
7 Miller LL, et al; A randomized, double-blind, placebo-controlled trial of transfer factor as adjuvant therapy for malignant melanoma. (Cancer, 1988 Apr, Abstract available) [MEDLINE]
8 Banks JB, et al; Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol. (Biochim Biophys Acta, 1988 Jul, Abstract available) [MEDLINE]
9 Babkina GT, et al; Affinity labeling at the A-site of Escherichia coli ribosomes by a non-hydrolyzable gamma-amide analog of GTP. (Biochimie, 1988 May, Abstract available) [MEDLINE]
10 Seifried SE, et al; Fluorescent modification of the cysteine 202 residue of Escherichia coli transcription termination factor rho. (J Biol Chem, 1988 Sep, Abstract available) [MEDLINE]
11 Lukács K, et al; Adult chronic granulomatosis disease-like neutrophil granulocyte disorder corrected by dialysable leukocyte extract. (Allergol Immunopathol (Madr), 1988 Mar, Abstract available) [MEDLINE]
12 Maldonado PE, et al; Growth factors modulate junctional cell-to-cell communication. (J Membr Biol, 1988 Dec, Abstract available) [MEDLINE]
13 Vijgenboom E, et al; The elongation factor EF-Tu from E. coli binds to the upstream activator region of the tRNA-tufB operon. (Nucleic Acids Res, 1988 Nov, Abstract available) [MEDLINE]
14 Collins MK, et al; Transfer of functional EGF receptors to an IL3-dependent cell line. (J Cell Physiol, 1988 Nov, Abstract available) [MEDLINE]
15 Chinali G, et al; Action of erythromycin and virginiamycin S on polypeptide synthesis in cell-free systems. (Biochim Biophys Acta, 1988 Nov, Abstract available) [MEDLINE]
16 Jakubowski H; Negative correlation between the abundance of Escherichia coli aminoacyl-tRNA families and their affinities for elongation factor Tu-GTP. (J Theor Biol, 1988 Aug, Abstract available) [MEDLINE]
17 Van Delft JH, et al; Control of the tRNA-tufB operon in Escherichia coli. 3. Feedback inhibition of tufB expression by an EF-Tu with a deletion in the guanine-nucleotide-binding domain. (Eur J Biochem, 1988 Aug, Abstract available) [MEDLINE]
18 Abrahams JP, et al; Zone-interference gel electrophoresis: a new method for studying weak protein-nucleic acid complexes under native equilibrium conditions. (Nucleic Acids Res, 1988 Nov, Abstract available) [MEDLINE]
19 Clark DJ, et al; A yeast sigma composite element, TY3, has properties of a retrotransposon. (J Biol Chem, 1988 Jan, Abstract available) [MEDLINE]
20 Van Delft JH, et al; Control of the tRNA-tufB operon in Escherichia coli. 2. Mechanisms of the feedback inhibition of tufB expression studied in vivo and in vitro. (Eur J Biochem, 1988 Aug, Abstract available) [MEDLINE]
21 Van Delft JH, et al; Control of the tRNA-tufB operon in Escherichia coli. 1. rRNA gene dosage effects and growth-rate-dependent regulation. (Eur J Biochem, 1988 Aug, Abstract available) [MEDLINE]
22 Sandmeyer SB, et al; Sigma elements are position-specific for many different yeast tRNA genes. (Nucleic Acids Res, 1988 Feb, Abstract available) [MEDLINE]
23 Rosenberg SA; The development of new immunotherapies for the treatment of cancer using interleukin-2. A review. (Ann Surg, 1988 Aug, Abstract available) [MEDLINE]
24 Moazed D, et al; Interaction of elongation factors EF-G and EF-Tu with a conserved loop in 23S RNA. (Nature, 1988 Jul, Abstract available) [MEDLINE]
25 Church WR, et al; A conserved epitope on several human vitamin K-dependent proteins. Location of the antigenic site and influence of metal ions on antibody binding. (J Biol Chem, 1988 May, Abstract available) [MEDLINE]
26 Kosano H, et al; Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid. (Cancer Res, 1988 Nov, Abstract available) [MEDLINE]
27 Allan B, et al; Heat shock response of Pseudomonas aeruginosa. (J Bacteriol, 1988 Aug, Abstract available) [MEDLINE]
28 Bar RS, et al; IGF receptors in myocardial capillary endothelium: potential regulation of IGF-I transport to cardiac muscle. (Biochem Biophys Res Commun, 1988 Apr, Abstract available) [MEDLINE]
29 Brannon PM, et al; Effects of epidermal growth factor, insulin and insulin-like growth factor I on rat pancreatic acinar cells cultured in serum-free medium. (Pancreas, 1988, Abstract available) [MEDLINE]
30 Collier M, et al; Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. (Hum Reprod, 1988 Nov, Abstract available) [MEDLINE]
31 von Rüden T, et al; Expression of functional human EGF receptor on murine bone marrow cells. (EMBO J, 1988 Sep, Abstract available) [MEDLINE]
32 Church WR, et al; An inhibitory monoclonal antibody to factor X that blocks prothrombin activation but not prothrombinase enzyme assembly. (Blood, 1988 Dec, Abstract available) [MEDLINE]
33 Robertson B, et al; Neuropeptide regulation of inflammatory and immunologic responses. The capacity of alpha-melanocyte-stimulating hormone to inhibit tumor necrosis factor and IL-1-inducible biologic responses. (J Immunol, 1988 Jun, Abstract available) [MEDLINE]
34 Colburn NH, et al; Comparison of mouse pro-1 and pro-2 transfectants for responses to tumor promoters and antipromoters. (Cancer Res, 1988 Nov, Abstract available) [MEDLINE]
35 Pai JK, et al; Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. (Biochem Biophys Res Commun, 1988 Jan, Abstract available) [MEDLINE]
36 Cosby RL, et al; Elevated plasma atrial natriuretic factor and vasopressin in high-altitude pulmonary edema. (Ann Intern Med, 1988 Nov, Abstract available) [MEDLINE]
37 Silva CL, et al; Tumor necrosis factor (cachectin) mediates induction of cachexia by cord factor from mycobacteria. (Infect Immun, 1988 Dec, Abstract available) [MEDLINE]
38 Barry EL, et al; Factor XIII cross-linking of fibronectin at cellular matrix assembly sites. (J Biol Chem, 1988 Jul, Abstract available) [MEDLINE]
39 Hamel E, et al; Transforming growth factor beta as a potent promoter in two-stage BALB/c 3T3 cell transformation. (Cancer Res, 1988 May, Abstract available) [MEDLINE]
40 Emoto N, et al; The effect of tumor necrosis factor/cachectin on follicle-stimulating hormone-induced aromatase activity in cultured rat granulosa cells. (Biochem Biophys Res Commun, 1988 Jun, Abstract available) [MEDLINE]
41 Hermansson M, et al; Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation. (Proc Natl Acad Sci U S A, 1988 Oct, Abstract available) [MEDLINE]
42 Downs SM, et al; Induction of maturation in cumulus cell-enclosed mouse oocytes by follicle-stimulating hormone and epidermal growth factor: evidence for a positive stimulus of somatic cell origin. (J Exp Zool, 1988 Jan, Abstract available) [MEDLINE]
43 Jones FS, et al; A cDNA clone for cytotactin contains sequences similar to epidermal growth factor-like repeats and segments of fibronectin and fibrinogen. (Proc Natl Acad Sci U S A, 1988 Apr, Abstract available) [MEDLINE]
44 Wu JH, et al; The product of the F plasmid transfer operon gene, traF, is a periplasmic protein. (J Bacteriol, 1988 Aug, Abstract available) [MEDLINE]
45 Fukuma K, et al; Immunologic and clinical studies on murine experimental autoimmune gastritis induced by neonatal thymectomy. (Gastroenterology, 1988 Feb, Abstract available) [MEDLINE]
46 Filetici E, et al; R-plasmids in Salmonella isolates from sporadic cases of gastroenteritis. (Eur J Epidemiol, 1988 Sep, Abstract available) [MEDLINE]
47 Carr BR, et al; The effects of alpha-human atrial natriuretic polypeptide on steroidogenesis by fetal zone cells of the human fetal adrenal gland. (Am J Obstet Gynecol, 1988 Dec, Abstract available) [MEDLINE]
48 Miyawaki S, et al; Marked acceleration of the autoimmune disease in MRL-lpr/lpr mice by the influence of the Yaa gene from BXSB mice. (Lab Anim Sci, 1988 Jun, Abstract available) [MEDLINE]
49 Knight KR, et al; Effect of the vasodilator peptides calcitonin gene-related peptide and atriopeptin on rabbit microvascular blood flow. Preliminary communication. (Br J Plast Surg, 1988 Mar, Abstract available) [MEDLINE]
50 Ruschen S, et al; An ELISA for IgA, IgG and IgM-RF measurement. I. Parameters of the assay. (Scand J Rheumatol Suppl, 1988, Abstract available) [MEDLINE]
51 Traxler BA, et al; Evidence that DNA helicase I and oriT site-specific nicking are both functions of the F TraI protein. (J Mol Biol, 1988 Nov, Abstract available) [MEDLINE]
52 Fox TD, et al; Plasmids can stably transform yeast mitochondria lacking endogenous mtDNA. (Proc Natl Acad Sci U S A, 1988 Oct, Abstract available) [MEDLINE]
53 Potapov AP, et al; The role of a template sugar-phosphate backbone in the ribosomal decoding mechanism. Comparative study of poly(U) and poly(dT) template activity. (J Mol Biol, 1988 Oct, Abstract available) [MEDLINE]
54 Fennerty AG, et al; The transfer factor and its subdivisions in patients with pulmonary emboli. (Eur Respir J, 1988 Feb, Abstract available) [MEDLINE]
55 Miyazaki M, et al; Peptide elongation factor 1 from yeasts: purification and biochemical characterization of peptide elongation factors 1 alpha and 1 beta (gamma) from Saccharomyces carlsbergensis and Schizosaccharomyces pombe [published erratum appears in J Biochem (Tokyo) 1988 May;103(5):900] (J Biochem (Tokyo), 1988 Mar, Abstract available) [MEDLINE]
56 Uritani M, et al; Role of yeast peptide elongation factor 3 (EF-3) at the AA-tRNA binding step. (J Biochem (Tokyo), 1988 Jul, Abstract available) [MEDLINE]
57 Cotes JE, et al; Lung function impairment as a guide to exercise limitation in work-related lung disorders. (Am Rev Respir Dis, 1988 May, Abstract available) [MEDLINE]
58 Kerr GD; Quality factors. (Health Phys, 1988 Aug, Abstract available) [MEDLINE]
59 Rooney RJ, et al; Transcriptional activity and factor binding are stimulated by separate and distinct sequences in the 5' flanking region of a mouse tRNAAsp gene. (Nucleic Acids Res, 1988 Mar, Abstract available) [MEDLINE]
60 Panniers R, et al; The effect of Mg2+ and guanine nucleotide exchange factor on the binding of guanine nucleotides to eukaryotic initiation factor 2. (J Biol Chem, 1988 Apr, Abstract available) [MEDLINE]
61 Shapiro AB, et al; Alteration of the nucleotide-binding site asymmetry of chloroplast coupling factor 1 by catalysis. (J Biol Chem, 1988 Oct, Abstract available) [MEDLINE]
62 Voigt G, et al; Measurements of transfer coefficients for 137Cs, 60Co, 54Mn, 22Na, 131I and 95mTc from feed into milk and beef. (Radiat Environ Biophys, 1988, Abstract available) [MEDLINE]
63 Chinn DJ, et al; Measurement technique influences the response of transfer factor (TICO) to salbutamol in patients with airflow limitation. (Eur Respir J, 1988 Jan, Abstract available) [MEDLINE]
64 Arnold GJ, et al; Functional dissection of 5' and 3' extragenic control regions of human tRNA(Val) genes reveals two different regulatory effects. (DNA, 1988 Mar, Abstract available) [MEDLINE]
65 Mizutani T, et al; Stronger affinity of reticulocyte release factor than natural suppressor tRNASer for the opal termination codon. (FEBS Lett, 1988 Jan, Abstract available) [MEDLINE]
66 Balmaceda JP, et al; Tubal embryo transfer as a treatment for infertility due to male factor. (Fertil Steril, 1988 Sep, Abstract available) [MEDLINE]
67 Sawadogo M; Multiple forms of the human gene-specific transcription factor USF. II. DNA binding properties and transcriptional activity of the purified HeLa USF. (J Biol Chem, 1988 Aug, Abstract available) [MEDLINE]
68 Kellerer AM, et al; Considerations on a revision of the quality factor. (Radiat Res, 1988 Jun, Abstract available) [MEDLINE]
69 Ogawa H, et al; Participation of suppressor-inducer cells in the suppression of adjuvant arthritis by transfer of spleen cells expanded by T cell growth factor. (Clin Exp Immunol, 1988 Jun, Abstract available) [MEDLINE]
70 Dean N, et al; Ordering promoter binding of class III transcription factors TFIIIC1 and TFIIIC2. (Mol Cell Biol, 1988 Aug, Abstract available) [MEDLINE]
71 Martin R, et al; Release factor competition is equivalent at strong and weakly suppressed nonsense codons. (Mol Gen Genet, 1988 Jul, Abstract available) [MEDLINE]
72 Curran JF, et al; Use of tRNA suppressors to probe regulation of Escherichia coli release factor 2. (J Mol Biol, 1988 Sep, Abstract available) [MEDLINE]
73 Calés C, et al; Differential subcellular distribution of guanine nucleotide exchange factor in suckling and adult rat brain. (Neurosci Lett, 1988 May, Abstract available) [MEDLINE]
74 Oehninger S, et al; In vitro fertilization and embryo transfer (IVF/ET): an established and successful therapy for endometriosis. (J In Vitro Fert Embryo Transf, 1988 Oct, Abstract available) [MEDLINE]
75 Brady MS, et al; Method to determine effect of antibiotics at residue levels on R-factor transfer. (J Assoc Off Anal Chem, 1988 Mar, Abstract available) [MEDLINE]
76 Sampson JR, et al; Biochemical and physical characterization of an unmodified yeast phenylalanine transfer RNA transcribed in vitro. (Proc Natl Acad Sci U S A, 1988 Feb, Abstract available) [MEDLINE]
77 Liang JY, et al; Hydration of CO2 by carbonic anhydrase: intramolecular proton transfer between Zn2+-bound H2O and histidine 64 in human carbonic anhydrase II. (Biochemistry, 1988 Nov, Abstract available) [MEDLINE]
78 Hausner TP, et al; The allosteric three-site model for the ribosomal elongation cycle. New insights into the inhibition mechanisms of aminoglycosides, thiostrepton, and viomycin. (J Biol Chem, 1988 Sep, Abstract available) [MEDLINE]
79 Horvath D, et al; Sequences between the internal control regions of tRNAArg of Drosophila melanogaster influence stimulation of transcription of the 5' flanking DNA. (Nucleic Acids Res, 1988 Mar, Abstract available) [MEDLINE]
80 Ogasawara T, et al; Inhibition of protein synthesis by a Vero toxin (VT2 or Shiga-like toxin II) produced by Escherichia coli O157:H7 at the level of elongation factor 1-dependent aminoacyl-tRNA binding to ribosomes. (Microb Pathog, 1988 Feb, Abstract available) [MEDLINE]
81 Marschalek R, et al; Identification of a protein factor binding to the 5'-flanking region of a tRNA gene and being involved in modulation of tRNA gene transcription in vivo in Saccharomyces cerevisiae. (Nucleic Acids Res, 1988 Jul, Abstract available) [MEDLINE]
82 Houssier C, et al; Effect of uridine dethiolation in the anticodon triplet of tRNA(Glu) on its association with tRNA(Phe). (J Biomol Struct Dyn, 1988 Jun, Abstract available) [MEDLINE]
83 Ricker RD, et al; Separation of formyl-methionyl transfer RNA, methionyl transfer RNA, and transfer RNAfmet using mixed-mode high-performance liquid chromatography on C6-modified aminopropylsilyl-hypersil. (Anal Biochem, 1988 Nov, Abstract available) [MEDLINE]
84 Westhof E, et al; Restrained refinement of two crystalline forms of yeast aspartic acid and phenylalanine transfer RNA crystals. (Acta Crystallogr A, 1988 Mar, Abstract available) [MEDLINE]
85 Kim KE, et al; Functional analysis of the interaction of a tissue-specific factor with an upstream enhancer element of the rat prolactin gene. (Mol Endocrinol, 1988 Dec, Abstract available) [MEDLINE]
86 Berger JW, et al; Brownian dynamics simulations of intramolecular energy transfer. (Biophys Chem, 1988 Jul, Abstract available) [MEDLINE]
87 Venuti SE, et al; Tissue distribution, purification and characterization of rat phosphatidylinositol transfer protein. (Biochim Biophys Acta, 1988 Dec, Abstract available) [MEDLINE]
88 Christianson TW, et al; A tridecamer DNA sequence supports human mitochondrial RNA 3'-end formation in vitro. (Mol Cell Biol, 1988 Oct, Abstract available) [MEDLINE]
89 Cox S, et al; Regulation of polypeptide-chain initiation in rat skeletal muscle. Starvation does not alter the activity or phosphorylation state of initiation factor eIF-2. (FEBS Lett, 1988 Nov, Abstract available) [MEDLINE]
90 Britton J; Is the carbon monoxide transfer factor diminished in the presence of diabetic retinopathy in patients with insulin-dependent diabetes mellitus? (Eur Respir J, 1988 May, Abstract available) [MEDLINE]
91 Wolff C, et al; Evidence that the two amino termini of plasma fibronectin are in close proximity: a fluorescence energy transfer study. (Biochemistry, 1988 May, Abstract available) [MEDLINE]
92 Yovich JM, et al; Preliminary results using pentoxifylline in a pronuclear stage tubal transfer (PROST) program for severe male factor infertility. (Fertil Steril, 1988 Jul, Abstract available) [MEDLINE]
93 Bommer UA, et al; Identification of proteins of the 40 S ribosomal subunit involved in interaction with initiation factor eIF-2 in the quaternary initiation complex by means of monospecific antibodies. (FEBS Lett, 1988 Jun, Abstract available) [MEDLINE]
94 Bommer UA, et al; Affinity labeling by a photoreactive GTP analogue of the alpha-subunit of eukaryotic initiation factor eIF-2 in different initiation complexes. (Biochem Int, 1988 Mar, Abstract available) [MEDLINE]
95 Yamaguchi K, et al; Dependence of O2 transfer conductance of red blood cells on cellular dimensions. (Adv Exp Med Biol, 1988, Abstract available) [MEDLINE]
96 Forman R, et al; Evidence for an adverse effect of elevated serum estradiol concentrations on embryo implantation. (Fertil Steril, 1988 Jan, Abstract available) [MEDLINE]
97 Van den Abbeel E, et al; Hyperstimulation: the need for cryopreservation of embryos. (Hum Reprod, 1988 Oct, Abstract available) [MEDLINE]
98 Kersten H; The nutrient factor queuine: biosynthesis, occurrence in transfer RNA and function. (Biofactors, 1988 Jan, Abstract available) [MEDLINE]
99 Thomas LK, et al; Codon choice and gene expression: synonymous codons differ in their ability to direct aminoacylated-transfer RNA binding to ribosomes in vitro. (Proc Natl Acad Sci U S A, 1988 Jun, Abstract available) [MEDLINE]
100 Hashiguchi R, et al; Dependence of instantaneous transfer function on regional ischemic myocardial volume. (Circ Res, 1988 Dec, Abstract available) [MEDLINE]
101 Garland F, et al; The MgADP-induced decrease of the SH1-SH2 fluorescence resonance energy transfer distance of myosin subfragment 1 occurs in two kinetic steps. (J Biol Chem, 1988 Aug, Abstract available) [MEDLINE]
102 Ann DK, et al; Retinol-regulated gene expression in human tracheobronchial epithelial cells. Enhanced expression of elongation factor EF-1 alpha. (J Biol Chem, 1988 Mar, Abstract available) [MEDLINE]
103 Sehgal A, et al; A constitutive promoter directs expression of the nerve growth factor receptor gene. (Mol Cell Biol, 1988 Aug, Abstract available) [MEDLINE]
104 Belgum JH, et al; Synaptic transfer of rod signals to horizontal and bipolar cells in the retina of the toad (Bufo marinus). (J Physiol (Lond), 1988 Feb, Abstract available) [MEDLINE]
105 Hara K, et al; Bipotential murine hemopoietic cell line (NFS-60) that is responsive to IL-3, GM-CSF, G-CSF, and erythropoietin. (Exp Hematol, 1988 May, Abstract available) [MEDLINE]
106 Picard A, et al; The cell cycle can occur in starfish oocytes and embryos without the production of transferable MPF (maturation-promoting factor). (Dev Biol, 1988 Jul, Abstract available) [MEDLINE]
107 Wolf D, et al; Retrovirus-mediated gene transfer of beta-nerve growth factor into mouse pituitary line AtT-20. (Mol Biol Med, 1988 Feb, Abstract available) [MEDLINE]
108 Zembala M, et al; T suppressor efferent circuit which affects contact sensitivity to picryl chloride: the late-acting, second nonspecific T suppressor factor bears I-A determinants which are responsible for the I-A genetic restriction in its interaction with its target cell. (Cell Immunol, 1988 Oct, Abstract available) [MEDLINE]
109 Nakano Y; Non-specific regulatory mechanism of contact sensitivity: the requirement of intermediate cells for non-specific suppressor factor (NSF) activity. (Immunology, 1988 Jun, Abstract available) [MEDLINE]
110 Zorn JR, et al; Ovarian stimulation for in-vitro fertilization combining administration of gonadotrophins and blockade of the pituitary with D-Trp6-LHRH microcapsules: pilot studies with two protocols. (Hum Reprod, 1988 Feb, Abstract available) [MEDLINE]
111 Ohki K, et al; Establishment and characterization of factor-dependent macrophage cell lines. (J Leukoc Biol, 1988 Dec, Abstract available) [MEDLINE]
112 Park MH, et al; Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage. (J Biol Chem, 1988 Oct, Abstract available) [MEDLINE]
113 Killion JW, et al; Determinants of immunity to murine salmonellosis: studies involving immunization with lipopolysaccharide-lipid A-associated protein complexes in C3H/HeJ mice. (FEMS Microbiol Immunol, 1988 Jan, Abstract available) [MEDLINE]
114 Khan I, et al; Success rate in gamete intrafallopian transfer using low and high concentrations of washed spermatozoa. (Fertil Steril, 1988 Dec, Abstract available) [MEDLINE]
115 Crapo RO, et al; Variability of the single-breath carbon monoxide transfer factor as a function of inspired oxygen pressure. (Eur Respir J, 1988 Jun, Abstract available) [MEDLINE]
116 Haque A, et al; Tolerance in rats by transplacental transfer of Dipetalonema viteae microfilariae: recognition of putative tolerogen(s) by antibodies that inhibit antigen-specific lymphocyte proliferation. (Eur J Immunol, 1988 Aug, Abstract available) [MEDLINE]
117 Klingler K, et al; Transformation of single myeloid precursor cells by the malignant histiocytosis sarcoma virus (MHSV): generation of growth-factor-independent myeloid colonies and permanent cell lines. (J Cell Physiol, 1988 Apr, Abstract available) [MEDLINE]
118 Engelke DR; Interaction of tRNA transcription factors with satellite I DNA from Xenopus laevis. (Gene, 1988, Abstract available) [MEDLINE]
119 Peritz LN, et al; The human growth hormone gene contains both positive and negative control elements. (J Biol Chem, 1988 Apr, Abstract available) [MEDLINE]
120 Raffa RB, et al; The analgesic defect of C57BL/6J-bgJ/bgJ (beige-J: Chediak-Higashi syndrome) mice transmitted by adoptive transfer of spleen cells to normal littermates. (Life Sci, 1988, Abstract available) [MEDLINE]
121 Wong KK, et al; Glutathione reductase: solvent equilibrium and kinetic isotope effects. (Biochemistry, 1988 Sep, Abstract available) [MEDLINE]
122 Tsubura A, et al; Intervention of T-cells in transportation of mouse mammary tumor virus (milk factor) to mammary gland cells in vivo. (Cancer Res, 1988 Nov, Abstract available) [MEDLINE]
123 Oluwole SF, et al; Mechanisms of immunologic unresponsiveness induced by ultraviolet-irradiated donor-specific blood transfusions and peritransplant cyclosporine. (Transplantation, 1988 Sep, Abstract available) [MEDLINE]
124 Ng YC, et al; Immune complexes and erythrocyte CR1 (complement receptor type 1): effect of CR1 numbers on binding and release reactions. (Clin Exp Immunol, 1988 Mar, Abstract available) [MEDLINE]
125 Holt JC, et al; Occurrence of platelet basic protein, a precursor of low affinity platelet factor 4 and beta-thromboglobulin, in human platelets and megakaryocytes. (Exp Hematol, 1988 May, Abstract available) [MEDLINE]
126 Frey B, et al; New function of vitamin B12: cobamide-dependent reduction of epoxyqueuosine to queuosine in tRNAs of Escherichia coli and Salmonella typhimurium. (J Bacteriol, 1988 May, Abstract available) [MEDLINE]
127 Tsutsui K, et al; Effects of photoperiod and temperature on the binding of follicle-stimulating hormone (FSH) to testicular preparations and plasma FSH concentration in the Djungarian hamster, Phodopus sungorus. (Endocrinology, 1988 Mar, Abstract available) [MEDLINE]
128 Davies AM; The trigeminal system: an advantageous experimental model for studying neuronal development. (Development, 1988, Abstract available) [MEDLINE]
129 Carson WG Jr; The role of lateral extra-articular procedures for anterolateral rotatory instability. (Clin Sports Med, 1988 Oct, Abstract available) [MEDLINE]
130 Brittle MP, et al; Induced type-B reticulum cell neoplasia in mice III. The importance of T-cell proliferation and cellular relocation in accessory cell transformation. (Br J Cancer, 1988 Apr, Abstract available) [MEDLINE]
131 Jaffrin MY, et al; Analysis of ultrafiltration and mass transfer in a bioartificial pancreas. (J Biomech Eng, 1988 Feb, Abstract available) [MEDLINE]
132 Dorshkind K; IL-1 inhibits B cell differentiation in long term bone marrow cultures. (J Immunol, 1988 Jul, Abstract available) [MEDLINE]
133 Roy AL, et al; Natural mRNA is required for directing Met-tRNA(f) binding to 40S ribosomal subunits in animal cells: involvement of Co-eIF-2A in natural mRNA-directed initiation complex formation. (Biochemistry, 1988 Oct, Abstract available) [MEDLINE]
134 Goldman JA, et al; First trimester bleeding in clinical IVF pregnancies. (Hum Reprod, 1988 Aug, Abstract available) [MEDLINE]
135 Fukuzawa H, et al; Structure and organization of Marchantia polymorpha chloroplast genome. III. Gene organization of the large single copy region from rbcL to trnI(CAU). (J Mol Biol, 1988 Sep, Abstract available) [MEDLINE]
136 Rubin JS; Effect of gamma rays on efficiency of gene transfer in DNA repair-proficient and -deficient cell lines. (Somat Cell Mol Genet, 1988 Nov, Abstract available) [MEDLINE]
137 Calzone FJ, et al; Developmental appearance of factors that bind specifically to cis-regulatory sequences of a gene expressed in the sea urchin embryo. (Genes Dev, 1988 Sep, Abstract available) [MEDLINE]
138 Weber Benarous A, et al; Retroviral-mediated transfer and expression of human beta-globin genes in cultured murine and human erythroid cells. (J Biol Chem, 1988 May, Abstract available) [MEDLINE]
139 Karsenty G, et al; Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter. (J Biol Chem, 1988 Sep, Abstract available) [MEDLINE]
140 Brackenbush LW, et al; Microdosimetric basis for exposure limits. (Health Phys, 1988 Aug, Abstract available) [MEDLINE]
141 Yovich JL, et al; Hormonal profiles and embryo quality in women with severe endometriosis treated by in vitro fertilization and embryo transfer. (Fertil Steril, 1988 Aug, Abstract available) [MEDLINE]
142 Yovich JL, et al; The treatment of normospermic infertility by gamete intrafallopian transfer (GIFT). (Br J Obstet Gynaecol, 1988 Apr, Abstract available) [MEDLINE]
143 Brandt U, et al; Characterisation of binding of the methoxyacrylate inhibitors to mitochondrial cytochrome c reductase. (Eur J Biochem, 1988 May, Abstract available) [MEDLINE]
144 Kohl DH, et al; Proline metabolism in N2-fixing root nodules: energy transfer and regulation of purine synthesis. (Proc Natl Acad Sci U S A, 1988 Apr, Abstract available) [MEDLINE]
145 Dancis J, et al; Placental transport of riboflavin: differential rates of uptake at the maternal and fetal surfaces of the perfused human placenta. (Am J Obstet Gynecol, 1988 Jan, Abstract available) [MEDLINE]
146 Alizadeh Khiavi K, et al; Biochemical nature and cellular origin of amyloid enhancing factor (AEF) as determined by anti-AEF antibody. (Br J Exp Pathol, 1988 Oct, Abstract available) [MEDLINE]
147 Wong PC, et al; Gamete intrafallopian transfer (GIFT): an alternate method of conception in couples with unexplained infertility, endometriosis and oligo-asthenospermia. (Ann Acad Med Singapore, 1988 Apr, Abstract available) [MEDLINE]
148 Oremland EK; Work dynamics in family care of hemophilic children. (Soc Sci Med, 1988, Abstract available) [MEDLINE]
149 Radek JT, et al; A differential scanning calorimetric investigation of the domains of recombinant tissue plasminogen activator. (Arch Biochem Biophys, 1988 Dec, Abstract available) [MEDLINE]
150 Nickbarg EB, et al; Triosephosphate isomerase: removal of a putatively electrophilic histidine residue results in a subtle change in catalytic mechanism. (Biochemistry, 1988 Aug, Abstract available) [MEDLINE]
151 Méry J, et al; Tryptophan reduction and histidine racemization during deprotection by catalytic transfer hydrogenation of an analog of the luteinizing hormone releasing factor. (Int J Pept Protein Res, 1988 Apr, Abstract available) [MEDLINE]
152 Wang D, et al; Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity. (J Virol, 1988 Nov, Abstract available) [MEDLINE]
153 Rapp G, et al; Cloning and sequence analysis of a cDNA from human ovarian granulosa cells encoding the C-terminal part of human elongation factor 2. (Biol Chem Hoppe Seyler, 1988 Apr, Abstract available) [MEDLINE]
154 Rogers KR, et al; Iron-sulfur centers involved in methanogenic electron transfer in Methanobacterium thermoautotrophicum (delta-H). (Biochem Biophys Res Commun, 1988 May, Abstract available) [MEDLINE]
155 Aurelian L, et al; Antigen-specific immune-suppressor factor in herpes simplex virus type 2 infections of UV B-irradiated mice. (J Virol, 1988 Jul, Abstract available) [MEDLINE]
156 Arean CO, et al; Ion binding to cytochrome c. (Eur J Biochem, 1988 May, Abstract available) [MEDLINE]
157 Feldman M, et al; The reversal of the metastatic phenotype by gene transfer. (Ciba Found Symp, 1988, Abstract available) [MEDLINE]
158 Kyle JW, et al; Expression of human cation-independent mannose 6-phosphate receptor cDNA in receptor-negative mouse P388D1 cells following gene transfer. (J Biol Chem, 1988 Nov, Abstract available) [MEDLINE]
159 Dieli F, et al; Role of macrophages in bypassing the inhibitory activity of Newcastle disease virus on the T-suppressor-cell circuit which regulates contact sensitivity to picryl chloride. (Cell Immunol, 1988 Feb, Abstract available) [MEDLINE]
160 Murphy GM, et al; Cholinergic urticaria, passive transfer experiments from human to monkey. (Dermatologica, 1988, Abstract available) [MEDLINE]
161 Terness P, et al; Induction of a suppressive serum factor, prevention of sensitization, and prolongation of kidney graft survival in rats by transfusion with antibody-coated blood cells. (Transplantation, 1988 Dec, Abstract available) [MEDLINE]
162 Angelillo M, et al; Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects. (J Immunol, 1988 Dec, Abstract available) [MEDLINE]
163 Fabian I, et al; Therapeutic potential of recombinant granulocyte-macrophage colony-stimulating factor and interleukin-3 in murine B-cell leukemia. (Blood, 1988 Sep, Abstract available) [MEDLINE]
164 Sutedja TG, et al; Pulmonary function after bone marrow transplantation for chronic myeloid leukaemia. (Thorax, 1988 Mar, Abstract available) [MEDLINE]
165 Cefalu E, et al; Successful gamete intrafallopian transfer following failed artificial insemination by donor: evidence for a defect in gamete transport? (Fertil Steril, 1988 Aug, Abstract available) [MEDLINE]
166 Fairchild RL, et al; Soluble factors in tolerance and contact sensitivity to 2,4-dinitro-fluorobenzene in mice. IX. A monoclonal T cell suppressor molecule is structurally and serologically related to the alpha/beta T cell receptor. (J Immunol, 1988 Nov, Abstract available) [MEDLINE]
167 Ishikawa Y, et al; A change in apolipoprotein B expression is required for the binding of apolipoprotein E to very low density lipoprotein. (J Biol Chem, 1988 Feb, Abstract available) [MEDLINE]
168 Mitra B, et al; Characterization of three-subunit chloroplast coupling factor. (Biochemistry, 1988 Jan, Abstract available) [MEDLINE]
169 Szöllösi D, et al; Remodeling of mouse thymocyte nuclei depends on the time of their transfer into activated, homologous oocytes. (J Cell Sci, 1988 Dec, Abstract available) [MEDLINE]
170 Amano M, et al; Characteristics of work actions of shoe manufacturing assembly line workers and a cross-sectional factor-control study on occupational cervicobrachial disorders. (Sangyo Igaku, 1988 Jan, Abstract available) [MEDLINE]
171 Murphy ME, et al; Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes. (Proteins, 1988, Abstract available) [MEDLINE]
172 James AL, et al; Bronchial responsiveness, lung mechanics, gas transfer, and corticosteroid response in patients with chronic airflow obstruction. (Thorax, 1988 Nov, Abstract available) [MEDLINE]
173 Wasserman H, et al; Air kerma rate constants for radionuclides. (Eur J Nucl Med, 1988, Abstract available) [MEDLINE]
174 Weir DC, et al; Transfer factor for carbon monoxide in patients with diabetes with and without microangiopathy [see comments] (Thorax, 1988 Sep, Abstract available) [MEDLINE]
175 Meyer P, et al; A genomic DNA segment from Petunia hybrida leads to increased transformation frequencies and simple integration patterns. (Proc Natl Acad Sci U S A, 1988 Nov, Abstract available) [MEDLINE]
176 Riddell FG, et al; Surface charge effects upon membrane transport processes: the effects of surface charge on the monensin-mediated transport of lithium ions through phospholipid bilayers studied by 7Li-NMR spectroscopy. (Biochim Biophys Acta, 1988 Nov, Abstract available) [MEDLINE]
177 Giaretti W, et al; Flow cytometric evaluation of cell cycle characteristics during in vitro differentiation of chick embryo chondrocytes. (Cytometry, 1988 Jul, Abstract available) [MEDLINE]
178 Corris PA, et al; Effects of diffuse pleural thickening on respiratory mechanics. (Eur Respir J, 1988 Mar, Abstract available) [MEDLINE]
179 Koga T, et al; Characterization of a low-molecular-weight growth inhibitor formed by density-inhibited, tumorigenic V79 Chinese hamster cells. (Cancer Res, 1988 Jul, Abstract available) [MEDLINE]
180 Ameratunga R, et al; The alveolar carbon monoxide uptake fraction: a simple, alternative measure of carbon monoxide transfer. (Eur Respir J, 1988 Feb, Abstract available) [MEDLINE]
181 Harriott Smith TG, et al; Suppression of contact hypersensitivity by short-term ultraviolet irradiation: I. Immunosuppression by serum from irradiated mice. (Clin Exp Immunol, 1988 Jan, Abstract available) [MEDLINE]
182 Conley J, et al; Surgery on the buccal fat pad in masseter transfer. (Arch Otolaryngol Head Neck Surg, 1988 Mar, Abstract available) [MEDLINE]
183 Liu YQ, et al; Wounding effects of small fragments of different shapes at different velocities on soft tissues of dogs. (J Trauma, 1988 Jan, Abstract available) [MEDLINE]
184 Cheng XY, et al; Wounding properties of steel pellets with different velocities and quality on soft tissue of dogs. (J Trauma, 1988 Jan, Abstract available) [MEDLINE]
185 Niven RW, et al; Solute absorption from the airways of the isolated rat lung. I. The use of absorption data to quantify drug dissolution or release in the respiratory tract. (Pharm Res, 1988 Sep, Abstract available) [MEDLINE]
186 Lavy G, et al; Hyaluronidase removal of the cumulus oophorus increases in vitro fertilization. (J In Vitro Fert Embryo Transf, 1988 Oct, Abstract available) [MEDLINE]
187 Myre M, et al; Clinical, functional and pathological correspondence in early stage idiopathic pulmonary fibrosis: evidence for small airway obstruction 1-2. (Respiration, 1988, Abstract available) [MEDLINE]
188 Cox RA, et al; Suppression of T-lymphocyte response by Coccidioides immitis antigen. (Infect Immun, 1988 Jun, Abstract available) [MEDLINE]
189 Freist W, et al; Isoleucyl-tRNA synthetase from baker's yeast and from Escherichia coli MRE 600. Discrimination of 20 amino acids in aminoacylation of tRNA(Ile)-C-C-A. (Eur J Biochem, 1988 Apr, Abstract available) [MEDLINE]
190 Tsai SC, et al; Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. (J Biol Chem, 1988 Feb, Abstract available) [MEDLINE]
191 Smith TJ, et al; Hepatic N-acetyltransferases: selective inactivation in vivo by a carcinogenic N-arylhydroxamic acid. (Biochem Pharmacol, 1988 Feb, Abstract available) [MEDLINE]
192 Shaw RJ, et al; Lung function abnormalities in patients infected with the human immunodeficiency virus with and without overt pneumonitis. (Thorax, 1988 Jun, Abstract available) [MEDLINE]
193 Soejima T, et al; Acquisition of repertoires of suppressor T cells under the influence of macrophages. (J Mol Cell Immunol, 1988, Abstract available) [MEDLINE]
194 Boudouresque F, et al; Maturation of the pituitary-adrenal function in rat fetuses. (Neuroendocrinology, 1988 Oct, Abstract available) [MEDLINE]
195 OConnor C, et al; Collagenase and fibronectin in bronchoalveolar lavage fluid in patients with sarcoidosis. (Thorax, 1988 May, Abstract available) [MEDLINE]
196 Kofron JL, et al; Coordination of manganous ion at the active site of pyruvate, phosphate dikinase: the complex of oxalate with the phosphorylated enzyme. (Biochemistry, 1988 Jun, Abstract available) [MEDLINE]
197 Courtright JB, et al; Alteration of bacterial DNA structure, gene expression, and plasmid encoded antibiotic resistance following exposure to enoxacin. (J Antimicrob Chemother, 1988 Feb, Abstract available) [MEDLINE]
198 Claesson HE, et al; Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4. (Eur J Biochem, 1988 Apr, Abstract available) [MEDLINE]
199 Gong SS, et al; Functional anatomy of the simian virus 40 late promoter. (Virology, 1988 Apr, Abstract available) [MEDLINE]
200 Stein DC, et al; Restriction of plasmid DNA during transformation but not conjugation in Neisseria gonorrhoeae. (Infect Immun, 1988 Jan, Abstract available) [MEDLINE]

NLM database Documents

Record 1 from database: MEDLINE
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Title
Murine transfer factor. IV. Studies with genetically regulated immune responses.
Author
Rozzo SJ; Merryman CF; Kirkpatrick CH
Address
Conrad D. Stephenson Laboratory, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
Source
Cell Immunol, 1988 Aug, 115:1, 130-45
Abstract
Transfer factor-containing dialysates from mice that were either high or low responders to GAT10, GLA5, or ovalbumin were assayed for their ability to transfer delayed hypersensitivity to murine recipients of either high or low responder phenotype. Dialysates from high responder strains contained transfer factor that would transfer delayed hypersensitivity to both high and low responder recipients. These transfers were not restricted by disparities at the MHC or Igh loci. Identically prepared materials from low responder donors contained little or no transfer factor activity and would not transfer delayed hypersensitivity to either high or low responder recipients. Thus, administration of transfer factor transfers the high responder phenotype to low responder recipients. The data also suggest that production of transfer factor is regulated by Ir genes but that the immunologic activities of transfer factor are not.
Language of Publication
English
Unique Identifier
88295138

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MeSH Heading (Major)
Hypersensitivity, Delayed|ET/*GE/IM; Transfer Factor|*/AD/BI/GE
MeSH Heading
Animal; Carrier Proteins|IM; Dialysis; Dose-Response Relationship, Immunologic; H-2 Antigens|GE; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mice, Inbred C57BL; Peptides|IM; Serum Albumin, Bovine|IM; Species Specificity; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Publication Type
JOURNAL ARTICLE
ISSN
0008-8749
Country of Publication
UNITED STATES

Record 2 from database: MEDLINE
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Title
Transfer factor.
Author
Kirkpatrick CH
Address
Conrad D. Stephenson Laboratory, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Source
J Allergy Clin Immunol, 1988 May, 81:5 Pt 1, 803-13
Abstract
It has been more than 30 years since Dr. H. S. Lawrence first reported that it was possible to transfer delayed-type hypersensitivity from sensitized donors to unsensitized recipients with lysates of blood leukocytes. During recent years, research from several laboratories has demonstrated that this effect is immunologically specific. Although the molecules that possess this activity have not been completely characterized, there is a significant body of evidence that they are small polypeptides and that they can interact with antigen molecules in an immunologically specific manner. Studies with immune responses that are under genetic control have demonstrated that the ability of an animal to produce transfer factor is genetically regulated but that transfer of delayed hypersensitivity with transfer factor is not genetically restricted. In fact, when mice of low-responder phenotypes are administered transfer factor from high-responder donors, they express delayed hypersensitivity responses that are comparable to the high responders. Clinical studies have demonstrated that transfer factor is an efficacious method for immunotherapy of certain viral and fungal infections.
Language of Publication
English
Unique Identifier
88228780

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MeSH Heading (Major)
Transfer Factor|*/IM/TU
MeSH Heading
Animal; Human; Hypersensitivity, Delayed|IM; Mice; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.
Publication Type
JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN
0091-6749
Country of Publication
UNITED STATES

Record 3 from database: MEDLINE
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Title
De novo initiation of specific cell-mediated immune responsiveness in chickens by transfer factor (specific immunity inducer) obtained from bovine colostrum and milk.
Author
Wilson GB; Poindexter C; Fort JD; Ludden KD
Address
Amtron, Inc., Charleston, South Carolina.
Source
Acta Virol, 1988 Jan, 32:1, 6-18
Abstract
Transfer factors (TF) were prepared from colostrum and milk of bovines previously immunized with antigens obtained from Coccidioides immitis, infectious bovine rhinotracheitis virus, or from the viral agents responsible for avian Newcastle disease, laryngotracheitis disease or infectious bursal disease. The ability of bovine TF to transfer specific cell-mediated immune responsiveness to a markedly xenogenic species was studied using specific pathogen free (SPF) and standard commercial (SC) chickens as model recipients. Cell-mediated immune responsiveness was documented using one or more of the following for each antigen (organism) studied: (a) an in vitro chicken leukocyte (heterophil) migration inhibition assay; (b) delayed-wattle reactivity; or (c) protection from clinical disease. Chicken TFs obtained from spleens of immune donors were evaluated in parallel to bovine TF's in selected comparative studies. Bovine TF also referred to as specific immunity inducer (SII), and chicken TF were found to initiate antigen-specific cell-mediated immunity de novo in previously non-immune SPF chickens as well as in SC chickens despite the presence of maternally acquired humoral antibody which may serve as a "barrier" to immunization of SC chickens when commercially available vaccines are administered by parenteral routes. Bovine TF's specific for laryngotracheitis virus or infectious bursal disease virus afforded protection equal to that found for commercially available vaccines. Bovine TF's action was rapid (less than a day) and of relatively long duration at least 35 days.
Language of Publication
English
Unique Identifier
88238284

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MeSH Heading (Major)
Immunity, Cellular|*; Transfer Factor|BI/IP/*PD
MeSH Heading
Animal; Antigens, Viral|IM; Cattle; Chickens; Colostrum|IM; Female; Herpesvirus 1, Gallid|IM; Immunization; Infectious Bursal Disease Virus|IM; Male; Milk|IM; Newcastle Disease Virus|IM; Pregnancy; Species Specificity
Publication Type
JOURNAL ARTICLE
ISSN
0001-723X
Country of Publication
CZECHOSLOVAKIA

Record 4 from database: MEDLINE
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Title
Chromatographic and enzymatic effects on transfer factor-like activity from human leukocytes and porcine spleen dialysate.
Author
Karhumäki E; Marnela KM; Krohn K
Address
Institute of Biomedical Sciences, University of Tampere, Finland.
Source
Int J Biochem, 1988, 20:10, 1067-72
Abstract
1. The effect of dialysable transfer factor (TFd), derived from human leukocytes or porcine spleen cells, was measured using Listeria resistance in mice. 2. The molecular weight range of substance(s) containing TF-like activity is in the less than 3500 MW dialysis fraction on the basis of the capacity of peritoneal macrophages to produce superoxide anion (O2-). This biological activity is removed by heating at 56 degrees C. 3. After Sephadex G-10 chromatography of dialysates the significant activities are found in fractions III and IV of human leukocyte dialysate and in fractions of II and III of porcine spleen dialysate. 4. From enzymatic studies, most of the protective activity of both human leukocyte and porcine spleen dialysate is based on the action of small-molecular weight structures containing peptides and/or polynucleotides.
Language of Publication
English
Unique Identifier
89252383

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MeSH Heading (Major)
Leukocytes|*AN; Spleen|*AN; Transfer Factor|*IP/PD
MeSH Heading
Animal; Chromatography, Gel; Dialysis|MT; Drug Resistance, Microbial|DE; Enzymes; Heat; Human; Listeria|DE; Listeria Infections|PC; Mice; Molecular Weight; Support, Non-U.S. Gov't; Swine
Publication Type
JOURNAL ARTICLE
ISSN
0020-711X
Country of Publication
ENGLAND

Record 5 from database: MEDLINE
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Title
Transfer factor in Hodgkin's disease: a randomized clinical and immunological study.
Author
Hancock BW; Bruce L; Sokol RJ; Clark A
Address
University Department of Medicine, Royal Hallamshire Hospital, Sheffield, U.K.
Source
Eur J Cancer Clin Oncol, 1988 May, 24:5, 929-33
Abstract
Transfer factor (TF) was prepared from buffy coats obtained from 493 units of blood taken from healthy donors, including individuals convalescent from various viral infections. It was administered to 22 of 47 patients with Hodgkin's disease undergoing treatment and consenting to take part in this randomized study to determine if TF would enhance their immunity and/or reduce the incidence of subsequent infections. Skin test reactivity was markedly enhanced in those patients receiving TF as opposed to placebo but other immunological assessments showed no significant differences between the groups. TF was not shown to be of benefit in the prevention of infections (including varicella/zoster).
Language of Publication
English
Unique Identifier
89005279

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MeSH Heading (Major)
Hodgkin Disease|*IM; Transfer Factor|*TU
MeSH Heading
B-Lymphocytes|IM; Blood Cell Count; Cell Migration Inhibition; Chickenpox|PC; Clinical Trials; Double-Blind Method; Human; Immunity, Cellular; Immunoglobulins|AN; Leukocytes|IM; Lymphocyte Transformation; Receptors, Fc|AN; Support, Non-U.S. Gov't; T-Lymphocytes|IM
Publication Type
CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
ISSN
0277-5379
Country of Publication
ENGLAND

Record 6 from database: MEDLINE
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Title
Varicella-zoster virus IgG antibodies during primoinfection in competent and transfer factor modulated immunocompromised host: comparison of three indirect assays.
Author
Zachar V; Mayer V; Schmidtmayerová H
Address
Institute of Virology, Slovak Academy of Sciences, Bratislaya, Czechoslovakia.
Source
Acta Virol, 1988 May, 32:3, 243-51
Abstract
Ten patients with acute leukaemia and next three with Hodgkin's or non-Hodgkin's lymphoma, suffering from varicella-zoster-virus (VZV) primoinfection, were given 1 to 2 doses of ultrafiltrate of the human leukocytes lysate (LLU) containing transfer factor (TF) activity (1 dose being equivalent to the product of 10(8) leukocytes). Only LLU administered to patients with acute lymphocytic leukaemia (ALL) at early phases of the illness (days 1 and 2) displayed a notable benefit on the clinical course of varicella. No influence upon the infection, on the other hand, was observed following LLU administration to subjects with lymphoma. The convalescent levels of IgG antibodies to VZV, as detected by indirect immunoperoxidase assay to membrane antigen (IPAMA), demonstrated no significant difference between infected competent and immunocompromised untreated and LLU treated individuals. The performance characteristics of IPAMA are compared with indirect immunofluorescence method (IFA) and non-competitive enzyme-linked immunosorbent assay (ELISA) on the same panel of specimens.
Language of Publication
English
Unique Identifier
89022589

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MeSH Heading (Major)
Antibodies, Viral|*AN; Chickenpox|ET/*IM/TH; Herpesvirus 3, Human|*IM
MeSH Heading
Comparative Study; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Human; IgG|AN; Immunoenzyme Techniques; Leukemia|CO; Lymphoma|CO; Transfer Factor|TU
Publication Type
JOURNAL ARTICLE
ISSN
0001-723X
Country of Publication
CZECHOSLOVAKIA

Record 7 from database: MEDLINE
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Title
A randomized, double-blind, placebo-controlled trial of transfer factor as adjuvant therapy for malignant melanoma.
Author
Miller LL; Spitler LE; Allen RE; Minor DR
Address
Paul M. Aggelar Memorial Laboratory, Children's Hospital of San Francisco, California.
Source
Cancer, 1988 Apr, 61:8, 1543-9
Abstract
One hundred and sixty-eight evaluable patients participated in a randomized, double-blind study of transfer factor (TF) versus placebo as surgical adjuvant therapy of Stage I and Stage II malignant melanoma. Eighty-five patients received TF prepared from the leukocytes of healthy volunteer donors; eighty-three participants received placebo. Therapy was initiated within 90 days of resection of all evident tumor and continued until 2 years of disease-free survival or the occurrence of unresectable dissemination of melanoma. Known prognostic variables were similarly distributed in the treatment and control groups, documenting the randomization efficacy. Three endpoints were analyzed: disease-free interval, time to Stage III metastasis, and survival. After a median follow-up period of 24.75 months, there was a trend in favor of the placebo group with regard to all three endpoints and this was significant (P less than or equal to 0.05) for time to Stage III metastasis. These findings indicate that TF is not effective as surgical adjuvant therapy of malignant melanoma.
Language of Publication
English
Unique Identifier
88164707

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MeSH Heading (Major)
Melanoma|SU/*TH; Transfer Factor|*TU
MeSH Heading
Clinical Trials; Combined Modality Therapy; Double-Blind Method; Human; Random Allocation; Support, Non-U.S. Gov't
Publication Type
CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
ISSN
0008-543X
Country of Publication
UNITED STATES

Record 8 from database: MEDLINE
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Title
Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol.
Author
Banks JB; Wykle RL; OFlaherty JT; Lumb RH
Address
Biochemistry Group, Western Carolina University, Cullowhee, NC 28723.
Source
Biochim Biophys Acta, 1988 Jul, 961:1, 48-52
Abstract
Platelet activating factor (PAF) is a potent, proinflammatory lipid. PAF is synthesized in response to stimuli and is rapidly destroyed by specific acetylhydrolases. In order to express its biological activity, PAF and its metabolites are transported among subcellular membranes by as yet unexplained mechanisms. We report here an assay system using methylcarbamyl-PAF (CPAF, 1-O-hexadecyl-2-O-(N-methylcarbamyl)-sn-glycero-3-phosphocholine) and a vesicle-extrusion technique for examining protein-catalyzed intermembrane transfer of CPAF, and demonstrate the presence of proteins catalyzing the separate transfer of CPAF and diacyl phosphatidylcholine in macrophage cytosol. The CPAF transfer activity is heat- and trypsin-sensitive and elutes from gel-filtration columns well separated from proteins catalyzing the transfer of phosphatidylcholine.
Language of Publication
English
Unique Identifier
88252202

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MeSH Heading (Major)
Macrophages|*ME; Phospholipid Ethers|*ME; Platelet Activating Factor|*ME; Proteins|*ME
MeSH Heading
Animal; Biological Transport; Cattle; Cytosol|ME; Intracellular Membranes|ME; Kinetics; Organ Specificity; Rabbits; Support, U.S. Gov't, P.H.S.
Publication Type
JOURNAL ARTICLE
ISSN
0006-3002
Country of Publication
NETHERLANDS

Record 9 from database: MEDLINE
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Title
Affinity labeling at the A-site of Escherichia coli ribosomes by a non-hydrolyzable gamma-amide analog of GTP.
Author
Babkina GT; Jonák J; Karpova GG; Knorre DG; Rychlík I; Vladimirov SN
Address
Institute of Bioorganic Chemistry, Siberian Division of the Academy of Sciences, Novosibirsk, U.S.S.R.
Source
Biochimie, 1988 May, 70:5, 597-603
Abstract
gamma-Amides of GTP and affinity and photoaffinity derivatives of gamma-amides of GTP: gamma-anilide of GTP, gamma-(4-azido)anilide of GTP, gamma-[N-(4-azidobenzyl)-N-methyl]amide of GTP, gamma[4-N-(2-chloroethyl)-N-methylaminobenzyl]amide of GTP and gamma-[4-N-(2-oxoethyl)-N-methylaminobenzyl]amide of GTP substituted efficiently for GTP in the EF-Tu-dependent transfer of aminoacyl-tRNA to the ribosome but, in contrast to GTP, they were not hydrolyzed in this process. They represent a new class of non-hydrolyzable GTP analogs with preserved gamma-phosphodiester bond. The radioactive analog of GTP: gamma-[4-N-(2-chloroethyl)-N-methylamino[14C]benzyl]amide of GTP was used as an affinity labeling probe for the identification of components of the GTPase center formed in the EF-Tu-dependent transfer reaction of aminoacyl-tRNA to the ribosomal A-site. Within a six-component complex of poly(U)-programmed E. coli ribosomes with elongation factor Tu, Phe-tRNA(Phe) (at the A-site), tRNA(Phe) (at the P-site) and the [14C]GTP analog, mainly the ribosomal 23S RNA and to a lesser extent the ribosomal proteins L17, L21, S16, S21 and the ribosomal 16S RNA were labeled by the reagent. No significant modification of EF-Tu was detected.
Language of Publication
English
Unique Identifier
89000961

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MeSH Heading (Major)
Affinity Labels|*ME; Escherichia coli|*ME; Guanosine Triphosphate|*AA/ME; Ribosomes|*ME
MeSH Heading
Amides|ME; Binding Sites; GTP Phosphohydrolase|ME; Hydrolysis; Peptide Elongation Factor Tu|PH; Peptides|BI; Photochemistry; RNA, Transfer, Amino Acyl|ME
Publication Type
JOURNAL ARTICLE
ISSN
0300-9084
Country of Publication
FRANCE

Record 10 from database: MEDLINE
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Title
Fluorescent modification of the cysteine 202 residue of Escherichia coli transcription termination factor rho.
Author
Seifried SE; Wang Y; von Hippel PH
Address
Institute of Molecular Biology, University of Oregon, Eugene 97403.
Source
J Biol Chem, 1988 Sep, 263:27, 13511-4
Abstract
The lone cysteine residue (Cys-202) of transcription termination factor rho has been modified with the sulfhydryl-specific dyes 5-iodoacetamidofluorescein and 5-(2-[iodoacetyl)amino)ethyl)aminonaphthalene-1-sulfonic acid. Labeling with both dyes is specific for the Cys-202 residue and is at least 90% complete. Rho protein is an RNA-dependent ATPase and exists as a hexamer of identical subunits in its activated (RNA-liganded) form. We find that chemical modification of rho at Cys-202 does not significantly change the properties of the protein; subunit assembly, RNA binding, and poly(rC)-activated ATP hydrolysis are all relatively unperturbed by the covalent attachment of these fluorescent moieties. On the other hand, the spectral, quenching, and anisotropy properties of the fluorescent groups are all significantly modified by attachment to the protein. No energy transfer is seen between fluorescein-labeled subunits within rho hexamers, indicating that the Cys-202 residues on these subunits are located at least 40 A apart. These fluorescently labeled rho molecules should represent useful probes to study the conformations and inter- and intrasubunit geometries of this termination factor at various stages of its interaction with nascent RNA transcripts.
Language of Publication
English
Unique Identifier
88330870

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MeSH Heading (Major)
Cysteine|*; Escherichia coli|*AN; Fluorescent Dyes|*; Rho Factor|*/ME/PD; Transcription Factors|*/ME/PD
MeSH Heading
Adenosinetriphosphatase|ME; Chemistry; Cross-Linking Reagents; Energy Transfer; Fluoresceins; Macromolecular Systems; Naphthalenesulfonates; RNA|ME; Spectrophotometry; Sulfhydryl Reagents; Support, U.S. Gov't, P.H.S.; Transcription, Genetic|DE
Publication Type
JOURNAL ARTICLE
ISSN
0021-9258
Country of Publication
UNITED STATES

Record 11 from database: MEDLINE
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Title
Adult chronic granulomatosis disease-like neutrophil granulocyte disorder corrected by dialysable leukocyte extract.
Author
Lukács K; Szabó G; Schröder I; Szegedi G
Address
3rd Department of Medicine, University Medical School, Debrechen, Hungary.
Source
Allergol Immunopathol (Madr), 1988 Mar, 16:2, 121-5
Abstract
A 47 year old female presented with a septic clinical picture including fever, abscesses, late cachexia, and unmanageable by disease. Similar characteristics to chronic granulomatosis disease (CGD) seriously decreased intracellular killing activity and chemiluminescence, granulomas in the histology, and the role of genetic factors were found, suggesting that our case is CGD-like disorder, manifested in an adult. Dialysable leukocyte extract (DLE) therapy, complemented with fresh normal plasma, resulted in a striking clinical improvement and there was an increase in the in vitro PMNL intracellular killing activity, too. Although it is generally accepted that DLE derives from monocytes and lymphocytes, it is possible that DLE is a family of DNA-oligopeptide molecules, including factors derived from PMNLs which are capable of influencing PMNL function, transferring information from normal cells. Our results also suggest that it would be worth trying DLE in patients with classic CGD.
Language of Publication
English
Unique Identifier
88279301

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MeSH Heading (Major)
Neutrophils|IM/*PA; Phagocyte Bactericidal Dysfunction|CO/*TH; Transfer Factor|IP/*TU
MeSH Heading
Abscess|ET; Case Report; Chemotaxis, Leukocyte; Female; Human; Leukocytes|AN; Middle Age; Phagocytosis; Rosette Formation
Publication Type
JOURNAL ARTICLE
ISSN
0301-0546
Country of Publication
SPAIN

Record 12 from database: MEDLINE
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Title
Growth factors modulate junctional cell-to-cell communication.
Author
Maldonado PE; Rose B; Loewenstein WR
Address
Department of Physiology and Biophysics, University of Miami School of Medicine, Florida 33101.
Source
J Membr Biol, 1988 Dec, 106:3, 203-10
Abstract
The epidermal growth factor (EGF) and the platelet-derived growth factor (PDGF) inhibit gap junctional communication in the mammalian cell lines NRK and BalbC 3T3: cell-to-cell transfer of a 400-dalton tracer molecule is reduced and junctional conductance is reduced. The inhibition of cell-to-cell transfer is reversible and dose dependent; half-maximal effects are obtained at 10(-9) and 10(-11) M concentrations of EGF and PDGF, respectively. The response of junctional conductance is detectable within 2 min of EGF application and reaches a maximum within 10 min. It is among the earliest cellular responses to this growth factor and may be significant in the regulation of growth. The response is lacking in EGF receptor-deficient NIH 3T3 cells. The transforming factor beta (TGF beta) enhances junctional communication in BalbC 3T3: cell-to-cell transfer is increased over a period of 8 hr. But in NRK cells, where it upregulates EGF receptors, TGF beta reduces junctional communication synergistically with EGF.
Language of Publication
English
Unique Identifier
89216868

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MeSH Heading (Major)
Cell Communication|*; Growth Substances|*PH; Intercellular Junctions|*PH
MeSH Heading
Animal; Cell Membrane Permeability; Cells, Cultured; Mice; Microelectrodes; Platelet-Derived Growth Factor; Rats; Receptors, Cell Surface|PH; Receptors, Epidermal Growth Factor-Urogastrone|PH; Support, U.S. Gov't, P.H.S.; Transforming Growth Factors|PH
Publication Type
JOURNAL ARTICLE
ISSN
0022-2631
Country of Publication
UNITED STATES

Record 13 from database: MEDLINE
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Title
The elongation factor EF-Tu from E. coli binds to the upstream activator region of the tRNA-tufB operon.
Author
Vijgenboom E; Nilsson L; Bosch L
Address
Department of Biochemistry, University of Leiden, The Netherlands.
Source
Nucleic Acids Res, 1988 Nov, 16:21, 10183-97
Abstract
The polypeptide chain elongation factor EF-Tu of Escherichia coli is encoded by two genes, tufA and tufB, located in two different operons. Experiments in which either tufA or tufB was inactivated demonstrated that expression of the tRNA-tufB operon is dependent on a functioning tufA and thus on EF-Tu (1, to be published). In order to study a possible role of EF-Tu as trans-activator of the tRNA-tufB operon, we have investigated in vitro binding of an EF-Tu. GDP preparation to various DNA fragments of the operon. We demonstrate that specific binding occurs to a cis-acting region delimited from position -134 to the promoter, previously shown to enhance tufB transcription. Electrophoretic retardation assays reveal the formation of maximally three protein/DNA complexes, indicating that more than one protein molecule can bind to the DNA. The EF-Tu preparation used was obtained by affinity chromatography and appeared to be 95% pure. It lost its DNA binding activity upon further purification. That EF-Tu is nonetheless involved in the DNA binding is suggested by the observation that none of the three complexes is formed in the presence of kirromycin, an antibiotic that binds EF-Tu with high specificity. If so, EF-Tu.GDP most likely binds to the activator region of the tRNA-tufB operon in combination with another non-identified protein or component.
Language of Publication
English
Unique Identifier
89057457

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MeSH Heading (Major)
Escherichia coli|*GE/ME; Gene Expression Regulation|*; Genes, Bacterial|*; Genes, Structural|*; Operon|*; Peptide Elongation Factor Tu|*GE/ME; RNA, Transfer|*GE
MeSH Heading
DNA, Bacterial|GE/ME; Kinetics; Support, Non-U.S. Gov't
Publication Type
JOURNAL ARTICLE
ISSN
0305-1048
Country of Publication
ENGLAND

Record 14 from database: MEDLINE
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Title
Transfer of functional EGF receptors to an IL3-dependent cell line.
Author
Collins MK; Downward J; Miyajima A; Maruyama K; Arai K; Mulligan RC
Address
Whitehead Institute, Cambridge, Massachusetts 02142.
Source
J Cell Physiol, 1988 Nov, 137:2, 293-8
Abstract
Epidermal growth factor (EGF) is a small protein that acts as a mitogen for various epidermal, epithelial, and fibroblastic cells that bear specific EGF receptors. The molecule that binds EGF is a 175-kD transmembrane protein, with an extracellular ligand binding domain and an intracellular domain that possesses tyrosine kinase activity, thought to be involved in the mitogenic signalling process. Here we have constructed a recombinant murine retrovirus that transduces a human cDNA encoding the 175-kD protein and used this retrovirus to infect BAF3, a murine, bone marrow-derived cell line, which is dependent on the haematopoietic factor interleukin-3 (IL3) for its growth in culture. The EGF receptors expressed in the infected cells exhibit two affinity states, as well as EGF-stimulated autophosphorylation. Furthermore, EGF can replace IL3 in supporting short-term proliferation of these cells. These data identify functional properties of the EGF receptor upon expression of the 175-kD EGF binding protein in a haemotopoietic cell that does not express endogenous receptors. They also suggest that gene transfer of growth factor receptors to heterologous cells may allow novel growth stimuli to be exploited.
Language of Publication
English
Unique Identifier
89054145

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MeSH Heading (Major)
Interleukin-3|*PD; Receptors, Epidermal Growth Factor-Urogastrone|GE/*ME
MeSH Heading
Animal; Cell Line; DNA|ME; Epidermal Growth Factor-Urogastrone|PD; Mice; Molecular Weight; Protein-Tyrosine Kinase|ME; Retroviridae|GE; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Transduction, Genetic
Publication Type
JOURNAL ARTICLE
ISSN
0021-9541
Country of Publication
UNITED STATES

Record 15 from database: MEDLINE
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Title
Action of erythromycin and virginiamycin S on polypeptide synthesis in cell-free systems.
Author
Chinali G; Nyssen E; Di Giambattista M; Cocito C
Address
Istituto di Strutture Biologiche ed Ultrastruttura Cellulare, Ila FacoltÄa di Medicina, UniversitÄa di Napoli, Italy.
Source
Biochim Biophys Acta, 1988 Nov, 951:1, 42-52
Abstract
Erythromycin (a 14-membered macrolide) and virginiamycin S (a type B synergimycin) block protein biosynthesis in bacteria, but are virtually inactive on poly(U)-directed poly(Phe) synthesis. We have recently shown, however, that these antibiotics inhibit the in vitro polypeptide synthesis directed by synthetic copolymers: this effect is analyzed further in the present work. We were unable to find any consistent alteration produced by th