DMG

1.     N,N-DIMETHYLGLYCINE HYDROCHLORIDE (DMG)

          CHEMICAL FORMULA FOR DMG: 

                              (CH₃)₂ NCH₂ COOH

          CHEMICAL STRUCTURE FOR DMG:

                               CH₃                 H    O

                                     \          |      ||

                                        N---C---C---OH

                                      /          |

                              CH₃          H

          CHEMICAL FORMULA FOR DMG.HCl: 

                              (CH₃)₂ NCH₂ COOH.HCl

          CHEMICAL STRUCTURE FOR DMG.HCl:

                               CH₃       H     H    O                   

                                     \    |      |      ||               ₊

                              [          N──C──C──OH      ]     (Cl) ^─

                                      /           |                                     

                              CH₃          H

                                        (OR)

                                         +      Cl ^─ 

                              CH₃          H      H    O

                                    \      |       |      ||

                                        N──C──C──OH

                                    /             |

                              CH₃             H

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SYNONYMS (OTHER KNOWN NAMES OF THIS PRODUCT)

1.       N,N-DIMETHYLGLYCINE HYDROCHLORIDE.

2.          DMG.HCl

3.          DMG.

4.          PANGAMIC ACID.

5.          CALCIUM PANGAMATE.

6.          VITAMIN B-15.

1.          What is DMG ?.

          DMG (Dimethylglycine) is a Modified Amino Acid that is found in any living body.  DMG is produced within the cells of the living body from Choline and Betaine and is so classified as an “intermediary metabolite”.  DMG plays a crucial role in the respiratory cycle of the cells, transporting oxygen and serving as a potent methyl donor.

          DMG is found in nature in food grains such as Rice Bran, Rice Polish and Whole Grains.  It is also found in Apricot Karnols and Brewer’s Yeast etc.

2.       How does DMG work ?.

          In its primary action DMG helps in Absorption, Assimilation, Transport and Delivery of Oxygen to all the individual cells of the body.  Thus it is an enhanced provider of Vital Oxygen to the individual cells of the body.

          All the energy available to the body for work comes from a complex Biochemical reaction called the ATP cycle.  This cycle occurs within the Mitochondria - small bodies inside the cells often called the “powerhouse of the body”.  DMG is used to help transport the oxygen that breaks down glycogen (“blood sugar”) to fuel the ATP cycle.  This function of DMG has let researchers to study its impact on lactic acid production in the body.

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          Biochemically DMG functions in the body as an indirect methyl donor and serves as a source of 2-carbon species, and serves as mineral transporter - chelating agent.  The Nutritional and Physiological properties of DMG come from it being an Ergogenic (tending to increase work output) substance, an anti-stress nutrient, a cell antioxidant, and an immune response potentiator.

I.       END USE AS A NUTRITIONAL FEED SUPPLEMENT FOR HUMANS & ANIMALS.

1.       By virtue of its property of being an Oxygen provider to the cells of the body it has the following applications as a Nutritional supplement.

a.       It slows down the aging of the cells of the body thus retarding the aging of the body as a whole.

b)      By the same property of cellular oxygenation it acts as a Preventive for AIDS and CANCER.

c)       By virtue of being a methyl donor it increases immuno response of the body and hence makes the body resistant in general to all diseases.

2.       As a feed supplement for Horses, Cattle, Poultry, Fishery etc., for purposes of enhancement of Athletic Performance, Disease free growth through higher immunity, High quality Meat etc. etc.

3.       Immuno-modulation for imparting resistance to various diseases in Marine culturing, Aqua culturing, Fisheries, Hatcheries,  Poultries & Stud farms etc.

4.       Reduction and removal of ARTHRITIC PROBLEMS in humans.

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5.       As a Health Care Product and a Nutritional supplement for humans with the following benefits.

a)       Controls aging of cells.

b)      Transports oxygen that breaks down glycogen to fuel the ATP cycle.

c)       Prevents and relieves head aches, insomnia, shortness of breath, chest pains, symptoms of angina, cyanosis and other signs of Artereo Sclerosis (hardening of the arteries).

d)      Helps in the treatment of mental retardation, hepatitis and early cirrhosis of the liver.

e)       Reduces craving for alcohol in alcoholics.

f)       Arrests development of gangrene, eliminates pain, heals the ulcers in symptoms of artereo sclerosis of the lower limbs.

g)       Prevents cancer and other diseases by supplying sufficient oxygen to the body cells.

II.      END USE AS AN INTERMEDIATE IN THE CHEMICAL SYNTHESIS OF DRUGS FOR THE FOLLOWING APPLICATIONS.

1.       Vitamin K.pro Drugs.

2.       Synthesis of Tripeptides.

3.       Promoting the growth of OSMOTICALLY STRESSED E.Coli.

4.       In Wool Dyeing.

5.       Enhancing the performance in Athletes.

6.       As Immunostimulant & enhancement of Immunological response  in variety of Animals.

7.       Fungicidal formulations.

8.       In Gluconeogenesis corresponding to Liver & Kidney functions

9.       In the management of Vibrio-Anguillarum Infection.

10.     As Erythrocyte Cryoprotectants.

11.     As Liposome Cryoprotectants.

12.     Inhibition of Human-leukocyte Elastase.

13.     Ergogenic Nutritional supplementation in sporting animals such as dogs & horses etc.

14.     For Anti Viral & Anti Bacterial response in the management of meningococcal infection & encephalitis etc.

15.            To obtain excellent sterocontrol for the formation of Syn.products.

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16.            For Stimulation of the immune-response, Dimethylglycine is a nontoxic metabolite.

17.     Effects of N,N-Dimethylglycine on cardiorespiratory function and lactate production in throughbred horses show incremental tredmill performance.

18.     Dimethylglycine is tested for mutagenicity under potential nitrosation conditions with positive results.

19.     Effects of Dimethylgylcine on antibody response to influenza vaccination in horses has been studied and found positive.

20.     Dimethylglycine has positive contribution in reduction of mortality in pencillin induced seizures.

21.     Immunomodulating properties of Dimethylglycine in human being was carried out and the results were encouraging.

III.          END USE IN PHARMACEUTICALS:

Fungicides                             ------> Polyene macrolides.

Antibiotics                             ------> Tetracyclines.

Immunosuppressants          ------> Substd. macrolides, rapamycin oximes..

Antiallergens             ------> Cinnamic acid derivs.

Antiulcerants           ------> Thiazoles..

Lipoxygenase Inhibitors     ------> Substituted alkanols.

Leukotriene Antagonists ------> Substituted tetralins & chromans.

Renin Inhibitors               ------> Peptide analogs.

Platelet Aggreg. Inhibitors-----> Polyprenyl compounds.

Antiarrythmics                    ------> Isoquinolines.

Antiinflammatories    ------> Azetidinones.

Hmg-CoA Reductase Inhib.---> Mevinic acid derivatives.

Techykinin Antagonists ------> (indolylcarbonyl) peptides.

Oxytocin Antagonists           ------> Tricyclic diazepines.

Antitumour Agents   ------> Chartreusins.

Steroids                              ------> Aminosteroids, hydrocortisone derives.

IV.     END USE IN OTHER APPLICATIONS:

Cosmetics                          ------> Moisturizers and Nutrient.

Water Purifn. Filters           ------> Antiseptics.

Gas Absorbers             ------> Iron Phenylporphyrin complexes.

Agrochemicals                    ------> Sugarcane yield enhancer.

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